About the Product
Our most popular product for nutrient replenishment!
Zira Nourished Mind, formerly HAessentials, is a comprehensive product developed over years of research utilizing nutrients and herbals that have been scientifically studied to help neurological health.
After recommending these nutrients and herbals individually for patients, the decision was made to create a product containing the most evidence-based, clinically tested ones to ease with dosing and compliance. We used nutrients in their activated, “ready” forms as often as possible in this blend.
The ultimate goal is to treat the underlying imbalance leading to the pain, and other neurological symptoms, in a natural and safe manner. This product contains many nutrients that are supportive of the energy production pathways, which often need support in patients with imbalanced doshas.
Generally, when the dosha has been imbalanced for years, the body, in its chronically activated, stressed state, becomes depleted in nutrients. This blend, along with the ayurvedic formulas, creates a wonderful synergy in the path to wellness.
This specific product was developed by Dr. Gokani for her patients.
Serving Size: 4 Capsules (100% Vegetarian)
Servings per Container: 30
Proprietary complex – 575mg:
- Alpha lipoic acid
- Milk Thistle (Silybum marianum extract standardized to contain 80% silymarin)
- Green tea extract
- Petadolex® Butterbur (Petasides hybridus) extract (28-44:1) (root) (standardized to contain 7.5mg of petasin and isopetasin)
- CoQ10 (as Ubiquinol)
- Magnesium (as citrate and glycinate) – 600mg
- Vitamin D3 – 1000 iu
- Vitamin E (as mixed tocopherols) – 400 iu
- Thiamin (B1) – 50mg
- Riboflavin (B2) – 190mg
- Riboflavin-5-phosphate – 10mg
- Niacin (B3) – 150mg
- Vitamin B6 – 25mg
- Folic Acid – 400mcg
- Vitamin B12 (as methylcobalamin) – 200mcg
Other Ingredients: Rice flour, Magnesium Stearate, Silicon dioxide, Vegetable Capsule
Proprietary complex 575mg:
Alpha lipoic acid, Milk Thistle (Silybum marianum extract standardized to contain 80% silymarin), Green tea extract, Petadolex® Butterbur (Petasides hybridus) extract (28-44:1) (root) (standardized to contain 7.5mg of petasin and isopetasin), CoQ10 (as Ubiquinol)
Other ingredients: Rice flour, Magnesium Stearate, Silicon dioxide, vegetable capsule
Why were these ingredients chosen?
Magnesium citrate and glycinate chelate. Magnesium is one of the most essential nutrients to replenish in anyone suffering with pain. It is a cofactor, involved in the activation of over 300 enzymes in your body. Some of the benefits of magnesium supplementation include improved sleep, decreased anxiety, relaxation of muscles, improvement of glucose uptake and bone health, and decrease of blood vessel constriction. Studies of have documented the benefits of Magnesium in migraine, especially menstrual migraine. ¹,2,3 The Magnesium in this formula is a chelated form, with citrate and glycinate. This was specifically chosen due to its ability to be absorbed well from the digestive tract along with high tolerability (very few side effects)
Vitamin D (cholecalciferol) The fat-soluble Vitamin D is actually not a vitamin, but a hormone. Many of us do not receive adequate activation of Vitamin D due to lack of sunlight exposure or simply due to where we live. Also, inflammation may play a role in Vitamin D levels. Studies have documented low Vitamin D levels in migraine and links with Vitamin D deficiency with headaches 4,5,6
Vitamin E (mixed tocopherols) This vitamin is an antioxidant which is composed of eight, fat-soluble, compounds. It is linked to prevention of Alzheimer’s disease and can help boost your immune system along with improving the action of insulin, thus helping to regulate blood sugars. It is important to use the mixed tocopherols, as they prove more beneficial, and likely safer, than simply the d-alpha or d-l alpha form of Vitamin E found in most supplements.
Vitamin B1 (Thiamine) This vitamin is necessary as it helps the body adapt to stress (and avoid adrenal burnout). It is necessary for energy production, thyroid hormone metabolism and needed for proper nerve function. This vitamin can be depleted with the use of oral contraceptives.
Riboflavin/Riboflavin 5 phosphate Vitamin B2, or Riboflavin, is associated with most of your body’s energy pathways. It is an essential vitamin for mitochondrial health, which is often found to be involved in migraine³ It is needed to regenerate glutathione, the strongest antioxidant produced in your body. B2 is also needed to convert other B vitamins into their active forms. Multiple studies have been done demonstrating the benefit of Vitamin B2 in migraine patients.8,9,10,11
B3 (Niacin) Vitamin B2, or niacin, is used in at least forty chemical reactions in your body. This vitamin is well known for its potential for lowering cholesterol (as it converts cholesterol to pregnenolone, a hormone that helps memory, amongst other things) and its role in mitochondrial energy production, which is often impaired in migraineurs.12 In addition, it is necessary in the metabolism of tryptophan and serotonin and to improve adrenal health. The study that showed it’s ability to decrease migraine is likely based on the above mentioned mechanisms.
B6 (Pyridoxine) This vitamin is essential for detoxifying chemicals, and is paired with more than 100 different enzymes. It is key to synthesis of several neurotransmitters, such as serotonin, which is linked to insomnia and migraine. Birth control pills and antidepressants can deplete this vitamin, as can age.
Methylated B12 (Methylcobalamin) This vitamin is synthesized by bacteria and may be low in vegetarians, vegans or those with digestive issues. Methylcobalamin is the active form of B12 that is useful in decreasing homocysteine levels, synthesizes SAM-e (which can be very helpful for mood disorders), and is needed to support adrenal health. This form also has been linked to lowering glutamate levels, which has been linked to migraine, memory and mood disorders 15 Due to it’s ability to scavenge nitric oxide, Vitamin B12 has been found to be helpful in migraine in various studies 15,16
CoQ10 (as Ubiquinol) This fat-soluble nutrient is unique in that it is made in nearly all of your body’s tissues. It is responsible for producing energy for cells, but must be in the ubiqunol form. The Ubiquinol form is the reduced, active, antioxidant form of CoQ10 and, as we age, we are less able to convert CoQ10 to ubinquinol. This is one of the strongest antioxidants available, protecting cells from free radical damage. This nutrient is well studied for its use in migraine headaches 17,18,19
Folic Acid Vitamin B9, or folic acid, is best known for it’s role in energy production. This vitamin detoxifies hormones, such as estrogen, along with heavy metals; is needed for conversion of dopamine; and has an important role in methylation. Studies have shown folic acid to be helpful in the treatment of migraine, especially if associated with elevated homocysteine levels.13,14 Alcohol, steroid medications, oral contraceptives and non-steroidal medications can deplete this important vitamin.
Alpha-lipoic acid This nutrient is essential to good health as it lowers excess calcium and copper, recycles CoQ10, glutathione, Vitamin C and Vitamin E, and helps insulin work more effectively. It also helps with cellular energy production and has been studied for it’s use in migraine.20
Petadolex (Butterbur) This plant has been used in Europe since 1972 for prevention of migraine. It acts as an anti-inflammatory by inhibiting leukotrienes and histamine. It is also a muscle relaxant and pain-reliever. In it’s natural state, however, butterbur also contains pyrrolizidine alkaloids (PA), which are known to be liver toxins. The butterbur used in this product has been proven to be free of PA’s. Many studies have been published establishing the effectiveness of butterbur in migraine both in adults and children. 21,22,23
Green tea extract Green tea, which comes from the Camellia sinesis plant, is one of the highest antioxidant teas known to mankind. The active component is EGCG, which has many health benefits. Many studies have been done showing it’s benefit in cardiovascular health, weight loss, and glutamate blocking effects. For this reason, it was chosen as a powerful addition to this formula.
Milk Thistle Silybum marianum, which is extracted from the Milk Thistle plant, has been used to treat kidney and liver disease. This plant decreases blood sugar, increase production of glutathione, helps with gallbladder disease, reduces inflammation and protects your liver from toxins. What is the Evidence?
1) Weaver K. Magnesium and migraine. Headache 1990;30:168. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 1996;16:257–263.
2) Facchinetti F, Sances G, Borella P, et al. Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 1991;31:298–304.
3) Wang F, Van Den Eeden SK, Ackerson LM, et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, doubleblind,placebo-controlled trial. Headache 2003;43:601– 610.
4) Prkash S., Mehta NC, Dabhi AS, Lakhani O, Khilari M. J Headache Pain. 2010 Aug;11(4):301-7. Epub 2010 May 13. The prevalence of headache may be related with the latitude: a possible role of Vitamin D insufficiency?
5) Thys-Jacobs S. Alleviation of migraines with therapeutic vitamin D and calcium. Headache 1994;34:590–592.
6) Thys-Jacobs S. Vitamin D and calcium in menstrual migraine. Headache 1994;34:544–546.
7) Smith CB. The role of riboflavin in migraine. Can Med Assoc J1946;54:589–591.
8) Gordon L. Riboflavin in migraine. Br Med J 1956;2:550–551.
9) Schoenen J, Lenaerts M, Bastings E. High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study. Cephalalgia 1994;14:328–329.
10)Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466– 470.
11) Boehnke C, Reuter U, Flach U, et al. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre.Eur J Neurol 2004;11:475– 477
12) Hall JA. Enhancing niacin’s effect for migraine. Cortlandt Forum 1991~July 1:46.
13) Di Rosa G, Attina S, Spano M, et al. Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms. Headache 2007;47:1342–1344.
14) Lea R, Colson N, Quinlan S, et al. The effects of vitamin supplementation and MTHFR ~C677T! genotype on homocysteine-lowering and migrainedisability. Pharmacogenet Genomics 2009;19:422– 428.
15) Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured corticalneurons. Eur J Pharmacol 1993 Sep 7;241(1):1-6.
16) Van der Kuy PHM, Merkus FWHM, Lohman JJHM, et al. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open,pilot study. Cephalalgia 2002;22:513–519.
17) Hershey AD, Powers SW, Vockell ALB, et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache2007;47:73–80.
18) Rozen TD, Oshinsky ML, Gebeline CA, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia 2002;22:137–141
19) and/or PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10in migraine
20) Magis D, Ambrosini A, Sandor P, et al. A randomized double-blind placebo controlled trial of thioctic acid in migraine prophylaxis. Headache 2007;47:52–57.
21) Phytomedicine 2006. Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review. Register for eNewsletter
22) Anon. International team of researchers find herbal extract to be effective in preventing migraine (press release). Bronx, NY: Albert Einstein College of Medicine. Dec. 28, 2004.
23) Lipton RB, Gobel H, Einhaupl KM, Wilks K, and Mauskop A. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology Dec. 28, 2004;63:2240-2244.
Indications and Dosage:
Zira Nourished Mind can be used to help the neurological system.
As a Preventative:
Recommended starting dose is 1 tablet daily for everyone, then slowly add 1 additional tablet daily, after one week, if tolerated.* Depending on severity of symptoms, increase to recommended dose listed below. For children less than age 18, please divide doses by one half.
For mild-moderate symptoms: 1 capsule with meals twice per day
For moderate-severe symptoms: 2 capsules with meals twice per day
For Abortive (as needed):
To relieve symptoms acutely: 2-4 caps every 8 hours during cycles (maximum of 8 caps daily)
(Monitor if patient –see medication interaction section below for whom to pay extra attention to)
Physician supervision is highly recommended for this product or any others that are started.
Warning: Consult your physician before use if you are pregnant, lactating, or have a medical condition or are taking any medication. Keep this and all medications out of the reach of children.
- If nausea, gas, loose stools, weakness, feeling of warmth, flushing, low blood pressure, reduced heart rate, double vision or slurred speech occur, reduce dose and speak to a health care professional immediately. These may be signs of Magnesium and/or B vitamin toxicity.
- If skin flushing, sensations of heat, stomach problems, or dry skin occur, this may be secondary to niacin. Pitta individuals with a high “heat state” may get this reaction more often than others. Follow pitta balancing lifestyle and dietary guidelines. Usually these symptoms resolve after a few weeks of use. Speak to your health care provider for remedies on how to reduce flushing.
- Diarrhea, nausea, stomach pain, and reduced effectiveness of birth control pills can occur with Milk Thistle, depending on dose.
- B vitamins may lead to a fluorescent yellow color to the urine, which is non-significant.
- For patients on blood pressure medications, on blood thinners, elderly, and those with kidney disease, please take product under physician supervision only. This is because Magnesium can lower blood pressure and should be monitored if one has kidney disease.
- Vitamin E and CoQ10 are potential blood thinners so monitoring is needed if combining with an anticoagulant
- If you are taking a statin drug, please discuss the addition of niacin with your health care provider.
- Folic acid could interact with certain seizure medications, so please discuss with your physician prior to utilizing this supplement.